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The purpose of the GERM (Genetically Evolved Receptor Models) program is to develop three-dimensional atom-based models of previously uncharacterized receptor sites, starting from a small structure-activity series of active and inactive compounds (3 or more structures).

The GERM program uses a genetic algorithm to construct and improve models so that calculated drug-receptor binding energies correlate with experimentally measured bioactivities for the known series of compounds. Other structures may then be docked into the receptor site models and bioactivities may be predicted. The models can be used with other drug design software to search 3-D databases or to design de novo novel ligands.

Current Version:   4.0

License Type:   Commercial

Home Site:

Source Code Availability:   Yes

Available Binary Packages:

  • Debian Package:   No
  • RedHat RPM Package:   No
  • Other Packages:   No

Targeted Platforms:

GERM is written in ANSI-C and has been successfully compiled on SGI-Unix, DOS, etc., should also work on Linux.

Software/Hardware Requirements:

C Compiler

Other Links:
J. Medicinal Chem., 37, 2527-2536 (1994).

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